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KMID : 0370220100540020097
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Yakhak Hoeji
2010 Volume.54 No. 2 p.97 ~ p.101
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Effects of N-Acetyl Cysteine and Silymarin on 1-Bromopropane-induced Hepatotoxicity in Mice
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Lee Sang-Kyu
Kang Mi-Jeong
Jeon Tae-Won
Jeong Tae-Cheon
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Abstract
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Recently, it was found that the formation of reactive metabolites by cytochrome P450s as well as the depletion of glutathione would play important roles in hepatotoxicity induced by 1-bromopropane. In the present study, possible roles of anti-oxidants in 1-bromopropane-induced hepatotoxicity were investigated in male ICR mice. The hepatotoxicity induced by 1-bromopropane was significantly protected by the co-treatment with either N-acetyl cysteine or silymarin. 1-Bromopropane-induced decrease in hepatic glutathione level was significantly protected by the pretreatment with N-acetyl cysteine. Taken together, the present results indicated that the reduction of hepatic glutathione level caused by 1-bromopropane treatment might be associated in 1-bromopropane-induced hepatotoxicity in mice.
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KEYWORD
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1-bromopropane, hepatotoxicity, N-acetyl cysteine, silymarin, lipid peroxidation, in vivo
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